【药物名称】TNK-6123
化学结构式(Chemical Structure):
参考文献No.552498
标题:Design of MKC-442 (emivirine) analogues with improved activity against drug-resistant HIV mutants
作者:Hopkins, A.L.; Ren, J.; Tanaka, H.; Baba, M.; Okamoto, M.; Stuart, D.I.; Stammers, D.K.
来源:J Med Chem 1999,42(22),4500
合成路线图解说明:

The title compound was synthesized by sulfenylation of 1-(ethoxymethyl)-5-isopropyluracil (I) with dicyclohexyl disulfide (II) in the presence of lithium 2,2,6,6-tetramethylpiperidine in cold THF.

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