Proquazone, Arthrex-药物合成数据库

【药物名称】Proquazone, Arthrex

化学结构式(Chemical Structure):

参考文献No.	800750
标题:	Proquazone
作者:	Casta馿r, J.; Thorpe, P.
来源:	Drugs Fut 1976,1(11),540

合成路线图解说明: The condensation of 2-amino-4-methylbenzophenone (I) with isopropyl iodide (II) by means of sodium carbonate gives 4-methyl-2-isopropylaminobenzophenone (III), which is the cyclized with urethane (A) under the catalytic action of ZnCl2 at 190 C.

参考文献No.	900138
标题:	o-Isopropylaminobenzophenones
作者:	Ott, H.; Denzer, M.
来源:	DE 180550,1; FR 2002598; GB 1248428

合成路线图解说明: The condensation of 2-amino-4-methylbenzophenone (I) with isopropyl iodide (II) by means of sodium carbonate gives 4-methyl-2-isopropylaminobenzophenone (III), which is the cyclized with urethane (A) under the catalytic action of ZnCl2 at 190 C.