【药物名称】R-2HMP
化学结构式(Chemical Structure):
参考文献No.18962
标题:Aliphatic propargylamines as selective MAO-B inhibitors and as neuroprotective agents
作者:Yu, P.H.; Davis, B.A.; Boulton, A.A. (University of Saskatchewan)
来源:JP 1994505241; US 5169868; WO 9215551
合成路线图解说明:

The racemic compound was synthesized by alkylation of N-methylpropargylamine (I) with 2-bromoheptane (II) in refluxing EtOH, followed by conversion to the corresponding hydrochloride salt.

参考文献No.228600
标题:Aliphatic propargylamines: Potent, selective, irreversible monoamine oxidase B inhibitors
作者:Yu, P.H.; Davis, B.A.; Boulton, A.A.
来源:J Med Chem 1992,35(20),3705
合成路线图解说明:

The racemic compound was synthesized by alkylation of N-methylpropargylamine (I) with 2-bromoheptane (II) in refluxing EtOH, followed by conversion to the corresponding hydrochloride salt.

参考文献No.551552
标题:R-2HMP: An orally active agent combining independent antiapoptotic and MAO-B-inhibitory activities
作者:Berry, M.D.
来源:CNS Drug Rev 1999,5(2),105
合成路线图解说明:

For the synthesis of the optically pure (R)-enantiomer, racemic 2-heptylamine (III) was resolved by means of immobilized, recombinant Candida antarctica lipase. The required (R)-2-heptylamine (IV) was then converted to the title compound by sequential methylation and propargylation.

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