【药物名称】CF-1368
化学结构式(Chemical Structure):
参考文献No.41132
标题:Anti-viral pyrimidine nucleoside analogues
作者:Jones, G.; Balzarini, J.; McGuigan, C.; Yarnold, C.; De Clercq, E. (University College, Cardiff)
来源:EP 0980377; WO 9849177
合成路线图解说明:

Coupling of 5-iodo-2'-deoxyuridine (I) with 1-decyne (II) in the presence of cuprous iodide and tetrakis(triphenylphosphine)palladium furnished the 5-decynyl uridine derivative (III). This was then cyclized to the title furopyrimidinone by treatment with cuprous iodide and triethylamine in refluxing methanol.

参考文献No.555750
标题:Potent and selective inhibition of varicella-zoster virus (VZV) by nucleoside analogues with an unusual bicyclic base
作者:McGuigan, C.; Yarnold, C.J.; Jones, G.; Vel醶quez, S.; Barucki, H.; Brancale, A.; Andrei, G.; Snoeck, R.; De Clercq, E.; Balzarini, J.
来源:J Med Chem 1999,42(22),4479
合成路线图解说明:

Coupling of 5-iodo-2'-deoxyuridine (I) with 1-decyne (II) in the presence of cuprous iodide and tetrakis(triphenylphosphine)palladium furnished the 5-decynyl uridine derivative (III). This was then cyclized to the title furopyrimidinone by treatment with cuprous iodide and triethylamine in refluxing methanol.

参考文献No.607966
标题:Bicyclic nucleoside inhibitors of varicella-Zoster virus (VZV): The effect of terminal unsaturation in the side chain
作者:Srinivasan, S.; McGuigan, C.; Andrei, G.; Snoeck, R.; De clercq, E.; Balzarini, J.
来源:Bioorg Med Chem Lett 2001,11(3),391
合成路线图解说明:

Coupling of 5-iodo-2'-deoxyuridine (I) with 1-decyne (II) in the presence of cuprous iodide and tetrakis(triphenylphosphine)palladium furnished the 5-decynyl uridine derivative (III). This was then cyclized to the title furopyrimidinone by treatment with cuprous iodide and triethylamine in refluxing methanol.

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