【药物名称】
化学结构式(Chemical Structure):
参考文献No.555747
标题:Synthesis and biological evaluation of the first N-alkyl cage dimeric 4-aryl-1,4-dihydropyridines as novel nonpeptidic HIV-1 protease inhibitors
作者:Hilgeroth, A.; Wiese, M.; Billich, A.
来源:J Med Chem 1999,42(22),4729
合成路线图解说明:

Cyclocondensation of a mixture of benzylamine (I), ethyl propiolate (II) and benzaldehyde (III) in hot AcOH furnished dihydropyridine (IV). Photodimerization of this compound in a MeOH-THF solution gave rise to the cage dimer (V). Finally, reduction of the ester groups of (V) by means of LiAlH4 at low temperature produced the title tetraol compound.

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