Bezafibrate, BM-15075, Befizal, Bezalip Retard, Cedur, Bezatol, Bezalip-药物合成数据库

【药物名称】Bezafibrate, BM-15075, Befizal, Bezalip Retard, Cedur, Bezatol, Bezalip

化学结构式(Chemical Structure):

参考文献No.	47836
标题:	Phenoxyalkylcarbos鋟rederivate und Verfahren zur Herstellung derselben
作者:	Witte, E.C.; et al. (Boehringer Ingelheim GmbH)
来源:	DE 2149070; ZA 7206638

合成路线图解说明: The benzoylation of tyramine (2-(p-hydroxyphenyl)ethylamine) (I) with 4-chlorobenzoyl chloride (II) in pyridine gives 4-(4-chlorobenzoylaminoethyl)phenol (III), which by condensation with ethyl alpha-bromoisobutyrate (IV) by means of K2CO3 in refluxing butanone affords ethyl alpha-[4-(4-chlorobenzoylaminoethyl)phenoxy]isobutyrate (V). Finally, this compound is hydrolyzed with KOH in dioxane - water.

参考文献No.	800563
标题:	Bezafibrate
作者:	Casta馿r, J.; Thorpe, P.
来源:	Drugs Fut 1978,3(4),258

合成路线图解说明: The benzoylation of tyramine (2-(p-hydroxyphenyl)ethylamine) (I) with 4-chlorobenzoyl chloride (II) in pyridine gives 4-(4-chlorobenzoylaminoethyl)phenol (III), which by condensation with ethyl alpha-bromoisobutyrate (IV) by means of K2CO3 in refluxing butanone affords ethyl alpha-[4-(4-chlorobenzoylaminoethyl)phenoxy]isobutyrate (V). Finally, this compound is hydrolyzed with KOH in dioxane - water.