【药物名称】
化学结构式(Chemical Structure):
参考文献No.556865
标题:Synthesis of a new series of N-hydroxy, N-alkylamides of aminoacids as ligands of NMDA glycine site
作者:Pietra, C.; Delcanale, M.; Merlini, L.; Bergamaschi, M.; Ventura, P.; Servadio, V.; Villetti, G.; Redenti, E.; Ghidini, E.
来源:Eur J Med Chem 1999,34(9),711
合成路线图解说明:

Condensation of N-heptylhydroxylamine (I) with the protected glycine succinimidyl ester (II) produced the O-acyl intermediate (III), which spontaneously rearranged to the N-acyl analogue (IV). Then, cleavage of the amino protecting group of (IV) furnished the title N-hydroxy glycinamide.

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