【药物名称】
化学结构式(Chemical Structure):
参考文献No.557409
标题:alpha-Trifluoromethylated acyloins induce apoptosis in human oral tumor cell lines
作者:Kawase, M.; Sakagami, H.; Kusama, K.; Motohashi, N.; Saito, S.
来源:Bioorg Med Chem Lett 1999,9(21),3113
合成路线图解说明:

In a related procedure, the title hydroxy ketone was obtained from hydroxy acid (III) and trifluoroacetic anhydride.

参考文献No.558069
标题:Unusual reactions of secondary amino acids with trifluoroacetic anhydride: A novel access to alpha-trifluoromethylated acyloins
作者:Kawase, M.
来源:Tetrahedron Lett 1994,35(1),149
合成路线图解说明:

The title compound was obtained by several synthetic procedures. The Dakin-West reaction of N-benzoyl-N-methylphenylalanine (I) with trifluoroacetic anhydride and pyridine produced the intermediate alpha-amino ketone (II), which underwent easy hydrolysis to the required hydroxy ketone via the enolic form of amino ketone (II).

参考文献No.558070
标题:A convenient synthesis of alpha-trifluoromethylated and alpha-perfluoroalkylated acyloins from alpha-hydroxy acids
作者:Kawase, M.; Kurihara, T.
来源:Tetrahedron Lett 1994,35(44),8209
合成路线图解说明:

In a related procedure, the title hydroxy ketone was obtained from hydroxy acid (III) and trifluoroacetic anhydride.

参考文献No.558072
标题:Convenient synthesis of 1,1,1-trifluoro-4,5-diaza-2,4-alkadienes and 1-aryl-3,3,3-trifluoro-1-propanones
作者:Kamitori, Y.; et al.
来源:Synthesis 1989,(1),43
合成路线图解说明:

Alternatively, acylation of tert-butyl methyl hydrazone (IV) with trifluoroacetic anhydride in pyridine produced the diaza alkadiene (V). Subsequent acid hydrolysis of (V) gave rise to the desired alpha-hydroxy ketone.

Drug Information Express,Drug R&D,Chemical Database,Patent Search.
Copyright © 2006-2024 Drug Future. All rights reserved.Contact Us