-药物合成数据库

【药物名称】

化学结构式(Chemical Structure):

参考文献No.	38844
标题:	alpha-Substd. phenylpropionic acid deriv. and medicine containing the same
作者:	Kotake, J.; Nagao, Y.; Konno, F.; Sato, S.; Honda, H.; Ishii, F. (SSP Co., Ltd.)
来源:	CA 2247772; EP 0903343; JP 1999158144

合成路线图解说明: Debenzylation of propanamide (I) by means of H2 over Pd/C in EtOH/HOAc provides alcohol (II), which is then mesylated with methanesulfonyl chloride (MsCl) and Et3N in CH2Cl2 to yield derivative (III). Finally, coupling of (III) with quinazoline derivative (IV) by means of K2CO3 in DMF affords the desired compound.

参考文献No.	558187
标题:	Preparation of benzazine derivatives with hypoglycemic activity
作者:	Ishii, F.; Koya, H.; Honda, H.; Nagao, Y.; Kotake, J.; Konno, F.; Sato, S.; Koda, T.; Ito, Y.
来源:	19th Symp Med Chem (Nov 17 1999, Tokyo) 1999,Abst 1P-05

合成路线图解说明: Debenzylation of propanamide (I) by means of H2 over Pd/C in EtOH/HOAc provides alcohol (II), which is then mesylated with methanesulfonyl chloride (MsCl) and Et3N in CH2Cl2 to yield derivative (III). Finally, coupling of (III) with quinazoline derivative (IV) by means of K2CO3 in DMF affords the desired compound.