UCL-1848-药物合成数据库

【药物名称】UCL-1848

化学结构式(Chemical Structure):

参考文献No.	35324
标题:	Potassium channel blockers
作者:	Campos-Rosa, J.; Dunn, P.M.; Galanakis, D.; Ganellin, C.R.; Jenkinson, D.H.; Yang, D.; Chen, J. (University College London)
来源:	WO 9748705

合成路线图解说明: The condensation of 1,5-diaminopentane (II) with 4-chloroquinoline (I) produced the bis-quinoline derivative (III). This was then cyclized with 1,5-diiodopentane (IV), and the resulting macrocyclic compound was purified by preparative HPLC in the presence of trifluoroacetic acid to furnish the title bis trifluoroacetate salt.

参考文献No.	593348
标题:	Bis-quinolinium cyclophanes: 8,14-diaza-1,7(1,4)-diquinolinacyclo-tetradecaphane (UCL 1848), a highly potent and selective, nonpeptidic blocker of the apamin-sensitive Ca2+-activated K+ channel
作者:	Chen, J.-Q.; Galanakis, D.; Ganellin, C.R.; Dunn, P.M.; Jenkinson, D.H.
来源:	J Med Chem 2000,43(19),3478

合成路线图解说明: The condensation of 1,5-diaminopentane (II) with 4-chloroquinoline (I) produced the bis-quinoline derivative (III). This was then cyclized with 1,5-diiodopentane (IV), and the resulting macrocyclic compound was purified by preparative HPLC in the presence of trifluoroacetic acid to furnish the title bis trifluoroacetate salt.