PT-653-药物合成数据库

【药物名称】PT-653

化学结构式(Chemical Structure):

参考文献No.	45312
标题:	Pharmaceutically active cpds. and methods of use thereof
作者:	Rosowsky, A. (Dana-Farber Cancer Institute)
来源:	WO 0059884

合成路线图解说明: Title compound is obtained by condensation of 6-(bromomethyl)pteridine-2,4-diamine (I) with dibenz[b,f]azepine (II) by means of NaH in THF..

参考文献No.	559166
标题:	Structure-based design of selective inhibitors of dihydrofolate reductase: Synthesis and antiparasitic activity of 2,4-diaminopteridine analogues with a bridged diarylamine side chain
作者:	Rosowsky, A.; Cody, V.; Galitsky, N.; Fu, H.; Papoulis, A.T.; Queener, S.F.
来源:	J Med Chem 1999,42(23),4853

合成路线图解说明: Title compound is obtained by condensation of 6-(bromomethyl)pteridine-2,4-diamine (I) with dibenz[b,f]azepine (II) by means of NaH in THF..