EUK-189-药物合成数据库

【药物名称】EUK-189

化学结构式(Chemical Structure):

参考文献No.	36195
标题:	Synthetic catalytic free radical scavengers useful as antioxidants for prevention and therapy of disease
作者:	Malfroy-Camine, B.; Doctrow, S.R. (Eukarion, Inc.)
来源:	JP 1999507646; US 5696109; WO 9640148; WO 9640149

合成路线图解说明: Condensation of the salicylaldehyde derivative (I) with ethylenediamine (II) affords the bis-imine (III). The title manganese complex is then obtained by treatment of (III) with manganese diacetate in ethanol.

参考文献No.	693464
标题:	Salen-manganese complexes as catalytic scavengers of hydrogen peroxide and cytoprotective agents: structure-activity relationship studies
作者:	Marcus, C.B.; Huffman, K.; Doctrow, S.R.; Tocco, G.; Malfroy, E.; Adinolfi, C.A.; Kruk, H.; Baker, K.; Lazarowych, N.; Mascarenhas, J.; Malfroy, B.
来源:	J Med Chem 2002,45(20),4549

合成路线图解说明: Condensation of the salicylaldehyde derivative (I) with ethylenediamine (II) affords the bis-imine (III). The title manganese complex is then obtained by treatment of (III) with manganese diacetate in ethanol.