【药物名称】CKD-731
化学结构式(Chemical Structure):
参考文献No.41275
标题:Fumagillol derivs. and processes for preparing the same
作者:Chun, H.S.; Choi, N.S.; Lee, S.J.; Han, C.K.; Hong, C.I.; Hong, R.K.; Kim, J.W.; Moon, S.K.; Ahn, S.K. (Chong Kun Dang Corp.)
来源:US 6063812; WO 9959986
合成路线图解说明:

Treatment of 3,4,5-trimethoxycinnamic acid (I) with oxalyl chloride and pyridine produced acid chloride (II). This was then coupled with fumagillol (III), an hydrolyzed product of the fungal metabolite fumagillin, in the presence of NaH in THF to give the title trimethoxycinnamyl ester. Alternatively, fumagillol (III) was coupled with acid anhydride (IV) using DMAP in CH2Cl2.

合成路线图解说明:

4-(2-Dimethylaminoethoxy)cinnamic acid (I) was converted to acid chloride (II) upon treatment with thionyl chloride in refluxing benzene. This was then coupled with the sodium alkoxide of fumagillol (III) in THF to furnish the title compound.

参考文献No.562781
标题:Design and synthesis of highly potent fumagillin analogues from homology modeling for a human MetAP-2
作者:Han, C.K.; Ahn, S.K.; Choi, N.S.; Hong, R.K.; Moon, S.K.; Chun, H.S.; Lee, S.J.; Kim, J.W.; Hong, C.I.; Kim, D.; Yoon, J.H.; No, K.T.
来源:Bioorg Med Chem Lett 2000,10(1),39
合成路线图解说明:

Treatment of 3,4,5-trimethoxycinnamic acid (I) with oxalyl chloride and pyridine produced acid chloride (II). This was then coupled with fumagillol (III), an hydrolyzed product of the fungal metabolite fumagillin, in the presence of NaH in THF to give the title trimethoxycinnamyl ester. Alternatively, fumagillol (III) was coupled with acid anhydride (IV) using DMAP in CH2Cl2.

参考文献No.574740
标题:Synthesis of novel fumagillin analogs as antiangiogenic agents
作者:Griffith, E.C.; Dai, X.B.; Liu, J.O.
来源:219th ACS Natl Meet (March 26 2000, San Francisco) 2000,Abst MEDI 61
合成路线图解说明:

Treatment of 3,4,5-trimethoxycinnamic acid (I) with oxalyl chloride and pyridine produced acid chloride (II). This was then coupled with fumagillol (III), an hydrolyzed product of the fungal metabolite fumagillin, in the presence of NaH in THF to give the title trimethoxycinnamyl ester. Alternatively, fumagillol (III) was coupled with acid anhydride (IV) using DMAP in CH2Cl2.

Drug Information Express,Drug R&D,Chemical Database,Patent Search.
Copyright © 2006-2024 Drug Future. All rights reserved.Contact Us