【药物名称】TSU-68, SU-6668
化学结构式(Chemical Structure):
参考文献No.41327
标题:Pyrrole substd. 2-indolinone protein kinase inhibitors
作者:Tang, P.C.; Sun, L.; McMahon, G. (Sugen, Inc.)
来源:WO 9961422
合成路线图解说明:

Basic hydrolysis of the known 2,4-dimethyl-5-ethoxycarbonyl-3-(2-ethoxycarbonyl ethyl)pyrrole (I) and subsequent decarboxylation of the resulting diacid (II) in the presence of HCl furnished 2,4-dimethyl-3-pyrrolepropionic acid (III). Vilsmeier formylation of (III) employing dimethylformamide and POCl3 produced aldehyde (IV). The title compound was then obtained by condensation of aldehyde (IV) with oxindole (V) in the presence of pyrrolidine, followed by acid treatment of the intermediate (VI). Alternatively, direct condensation of aldehyde (IV) with oxindole (V) in the presence of NaOH gave rise to the title compound.

Drug Information Express,Drug R&D,Chemical Database,Patent Search.
Copyright © 2006-2024 Drug Future. All rights reserved.Contact Us