HI-443-药物合成数据库

【药物名称】HI-443

化学结构式(Chemical Structure):

参考文献No.	45038
标题:	Thiophene-ethyl thiourea cpds. and use
作者:	Ventatachalam, T.K.; Uckun, F.M. (Parker Hughes Institute)
来源:	US 6124324; WO 0078755

合成路线图解说明: Reaction of 2-amino-5-bromopyridine (I) with thiocarbonyl diimidazole (II) provided the thioimidazolide (III). This was then coupled with 2-(2-thienyl)ethyl amine (IV) to furnish the target thiourea.

参考文献No.	562635
标题:	N'-[2-(2-Thiophene)ethyl]-N'-[2-(5-bromopyridyl)] thiourea as a potent inhibitor of NNI-resistant and multidrug-resistant human immunodeficiency virus-1
作者:	Uckun, F.M.; Pendergrass, S.; Maher, D.; Zhu, D.; Tuel-Ahlgren, L.; Mao, C.; Venkatachalam, T.K.
来源:	Bioorg Med Chem Lett 1999,9(24),3411

合成路线图解说明: Reaction of 2-amino-5-bromopyridine (I) with thiocarbonyl diimidazole (II) provided the thioimidazolide (III). This was then coupled with 2-(2-thienyl)ethyl amine (IV) to furnish the target thiourea.