【药物名称】
化学结构式(Chemical Structure):
参考文献No.562475
标题:Synthesis of 2-(2-adamantyl)piperidines and structure anti-influenza virus a activity relationship study using a combination of NMR spectroscopy and molecular modeling
作者:Kolocouris, A.; Tataridis, D.; Fytas, G.; Mavromoustalkos, T.; Foscolos, G.B.; Kolocouris, N.; De Clercq, E.
来源:Bioorg Med Chem Lett 1999,9(24),3465
合成路线图解说明:

The condensation of adamantan-2-one (I) with 2-pyridyllithium (II) in THF/ethyl ether gives 2-(2-pyridyl)adamantan-2-ol (III), which is treated with dry HCl in ethanol to yield the pyridinium salt (IV). The hydrogenation of (IV) with H2 over PtO2 in ethanol affords 2-(2-piperidinyl)adamantan-2-ol (V), which is treated with SOCl2 in refluxing dichloromethane to provide the piperidinium chloride (VI). The dehydrochlorination of (VI) with KOH in refluxing ethanol yields the tetrahydropyridine (VIII), which is finally hydrogenated with NaBH4 in methanol.

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