【药物名称】
化学结构式(Chemical Structure):
参考文献No.562778
标题:6-Acylamino-2-[(alkylsulfonyl)oxy]-1H-isoindole-1,3-dione mechanism-based inhibitors of human leukocyte elastase
作者:Kerrigan, J.E.; Walters, M.C.; Forrester, K.J.; Crowder, J.B.; Christopher, L.J.
来源:Bioorg Med Chem Lett 2000,10(1),27
合成路线图解说明:

Condensation of 4-nitrophthalic anhydride (I) with O-benzyl hydroxylamine in refluxing toluene produced phthalimide (II). Catalytic transfer hydrogenation employing cyclohexene in the presence of Pd/C yielded 4-amino-N-hydroxyphthalimide (III), which was condensed with ethanesulfonyl chloride to give sulfonate (IV). Finally, acylation with acid chloride (V) furnished the title compound.

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