-药物合成数据库

【药物名称】

化学结构式(Chemical Structure):

参考文献No.	433354
标题:	Targeting nitric oxide (NO) delivery in vivo. Design of a liver-selective NO donor prodrug that blocks tumor necrosis factor-alpha-induced apoptosis and toxicity in the liver
作者:	Saavedra, J.E.; Billiar, T.R.; Williams, D.L.; Kim, Y.M.; Watkins, S.C.; Keefer, L.K.
来源:	J Med Chem 1997,40(13),1947

合成路线图解说明: Exposure of pyrrolidine (I) to NO in acetonitrile/ether in the presence of NaOMe in MeOH provides sodium 1-(pyrrolidin-1-yl)diazen-1-ium-1,2-diolate (II), which is converted into the desired product by reaction with bromomethyl acetate (III) in DMSO in the presence of Na2CO3 and silver acetate (HgOAc).

参考文献No.	563829
标题:	Esterase-sensitive nitric oxide donors of the diazeniumdiolate family: In vitro antileukemic activity
作者:	Saavedra, J.E.; Shami, P.J.; Wang, L.Y.; Davies, K.M.; Booth, M.N.; Citro, M.L.; Keefer, L.K.
来源:	J Med Chem 2000,43(2),261

合成路线图解说明: Exposure of pyrrolidine (I) to NO in acetonitrile/ether in the presence of NaOMe in MeOH provides sodium 1-(pyrrolidin-1-yl)diazen-1-ium-1,2-diolate (II), which is converted into the desired product by reaction with bromomethyl acetate (III) in DMSO in the presence of Na2CO3 and silver acetate (HgOAc).