【药物名称】
化学结构式(Chemical Structure):
参考文献No.477814
标题:Synthesis of Tn, sialyl Tn and HIV-1-derived peptide antigen conjugates having a lipid A analog as an immunoadjuvant for synthetic vaccines
作者:Miyajima, K.; Nekado, T.; Ikeda, K.; Achiwa, K.
来源:Chem Pharm Bull 1998,46(11),1676
合成路线图解说明:

Intermediate (VII) was coupled with beta-alanine benzyl ester (VIII) to give amide (IX). After hydrogenolysis of the benzyl ester of (IX), the acetate esters were removed by treatment with ammonia in MeOH, THF.

参考文献No.563960
标题:Lipid A and related compounds. XXXVII. Determination of favorable binding linkages of lipid A analog to antigen moiety for synthetic vaccines
作者:Ikeda, K.; Miyajima, K.; Shimizu, T.; Achiwa, K.
来源:Chem Pharm Bull 2000,48(1),32
合成路线图解说明:

Phenylsulfanyl glycoside (I) was coupled with serine derivative (II) in the presence of N-bromosuccinimide, iodine and tetrabutylammonium triflate yielding the serine glycoside (III). Reductive cleavage of the trichloroethoxy carbonyl group of (III) with Zn and HOAc afforded amine (IV), which was acylated with (R)-3-(tetradecanoyloxy)tetradecanoic acid (V) using DCC and HOBt. Hydrogenolysis of the benzyl ester (VI) over palladium black provided carboxylic acid (VII).

合成路线图解说明:

Intermediate (VII) was coupled with beta-alanine benzyl ester (VIII) to give amide (IX). After hydrogenolysis of the benzyl ester of (IX), the acetate esters were removed by treatment with ammonia in MeOH, THF.

参考文献No.564413
标题:Synthesis of TN and sialyl TN antigen-lipid an analog conjugates for synthetic vaccines
作者:Miyajima, K.; Nekado, T.; Ikeda, K.; Achiwa, K.
来源:Chem Pharm Bull 1997,45(9),1544
合成路线图解说明:

Intermediate (VII) was coupled with beta-alanine benzyl ester (VIII) to give amide (IX). After hydrogenolysis of the benzyl ester of (IX), the acetate esters were removed by treatment with ammonia in MeOH, THF.

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