UCL-1972-药物合成数据库

【药物名称】UCL-1972

化学结构式(Chemical Structure):

参考文献No.	42118
标题:	Non-imidazole aryloxy (or arylthio) alkylamines as histamine H3-receptor antagonists and their therapeutic applications
作者:	Stark, H.; Ligneau, X.; Garbarg, M.; Schunack, W.G.; Ganellin, C.R.; Lecomte, J.-M.; Arrang, J.-M.; Leurquin, F.; Sigurd, E.; Schwartz, J.-C. (Societe Civile Bioprojet)
来源:	EP 0978512

合成路线图解说明: The reaction of 4-nitrophenol (I) with 1,5-dibromopentane (II) and NaOH in refluxing water gives the aryl ether (III), which is finally condensed with pyrrolidine (IV) in refluxing ethanol.

参考文献No.	601720
标题:	Synthesis of potent non-imidazole histamine H3-receptor antagonists
作者:	Ganellin, C.; et al.
来源:	Arch Pharm 1998,331(12),395

合成路线图解说明: The reaction of 4-nitrophenol (I) with 1,5-dibromopentane (II) and NaOH in refluxing water gives the aryl ether (III), which is finally condensed with pyrrolidine (IV) in refluxing ethanol.