-药物合成数据库

【药物名称】

化学结构式(Chemical Structure):

参考文献No.	567499
标题:	Benzyl derivatives of 2,1,3-benzo- and benzothieno[3,2-a]thiadiazine 2,2-dioxides: First phosphodiesterase 7 inhibitors
作者:	Mart韓ez, A.; Castro, A.; Gil, C.; Miralpeix, M.; Segarra, V.; Domenech, T.; Beleta, J.; Palacios, J.M.; Ryder, H.; Miro, X.; Bonet, C.; Casacuberta, J.M.; Azorin, F.; Pina, B.; Puigdomenech, P.
来源:	J Med Chem 2000,43(4),683

合成路线图解说明: Benzothiadiazine S,S-dioxide (II) was obtained by a two-step condensation of methyl anthranylate (I) and sulfamoyl chloride following a reported procedure (1). The alkylation of (II) with 3,4-dichlorobenzyl chloride (III) in the presence of NaHCO3 furnished the title compound.

参考文献No.	803862
标题:
作者:
来源:	J Am Chem Soc 1962,841994-2000

合成路线图解说明: Benzothiadiazine S,S-dioxide (II) was obtained by a two-step condensation of methyl anthranylate (I) and sulfamoyl chloride following a reported procedure (1). The alkylation of (II) with 3,4-dichlorobenzyl chloride (III) in the presence of NaHCO3 furnished the title compound.