-药物合成数据库

【药物名称】

化学结构式(Chemical Structure):

参考文献No.	42254
标题:	Short oligonucleotides for the inhibition of VEGF expression
作者:	Bitonti, A.; Woessner, R.; Peyman, A.; Uhlmann, E. (Aventis Pharma Deutschland GmbH)
来源:	EP 0979869; WO 0008141

合成路线图解说明: Treatment of 10-hydroxycamptothecin (I) with EtOH and H2SO4 in the presence of FeCl3 produced 5-ethoxy-10-hydroxycamptothecin (II) along with minor amounts of the 5-hydroxy derivative (III). Hydrolysis of (II) to give (III) was effected using HCl in H2O-EtOH. Finally, acid-catalyzed condensation of (III) with 2,2,2-trifluoroethanol furnished the title compound.

参考文献No.	568775
标题:	Novel C-ring analogues of 20(S)-camptothecin. Part 3: Synthesis and their in vitro cytotoxicity of A-, B- and C-ring analogues
作者:	Subrahmanyam, D.; Sarma, V.M.; Venkateswarlu, A.; Sastry, T.V.; Srinivas, A.S.; Krishna, C.V.; Deevi, D.S.; Kumar, S.A.; Babu, M.J.; Damodaran, N.K.
来源:	Bioorg Med Chem Lett 2000,10(4),369

合成路线图解说明: Treatment of 10-hydroxycamptothecin (I) with EtOH and H2SO4 in the presence of FeCl3 produced 5-ethoxy-10-hydroxycamptothecin (II) along with minor amounts of the 5-hydroxy derivative (III). Hydrolysis of (II) to give (III) was effected using HCl in H2O-EtOH. Finally, acid-catalyzed condensation of (III) with 2,2,2-trifluoroethanol furnished the title compound.