【药物名称】
化学结构式(Chemical Structure):
参考文献No.569170
标题:Inhibition of Grb2 SH2 domain binding by non-phosphate-containing ligands. 2. 4-(2-Malonyl)phenylalanine as a potent phosphotyrosyl mimetic
作者:Gao, Y.; Luo, J.; Yao, Z.J.; Guo, R.; Zou, H.; Kelley, J.; Voight, J.H.; Yang, D.; Burke, T.R. Jr.
来源:J Med Chem 2000,43(5),911
合成路线图解说明:

Coupling between asparagine amide (I) and N-Fmoc-1-amino-cyclohexanecarboxylic acid (II) afforded dipeptide amide (III). Deprotection of the Fmoc group of (III) to give (IV) was carried out by treatment with piperidine in DMF. Subsequent coupling of dipeptide (IV) with the protected phenylalanine derivative (V) using diisopropyl carbodiimide (DIC) and HOBt furnished tripeptide (VI), and further cleavage of the Fmoc group provided (VII). Acylation of (VII) with tert-butyl oxalyl chloride (VIII) yielded amide (IX). The tert-butyl ester groups of (IX) were finally cleaved by treatment with trifluoroacetic acid.

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