Alternatively, the title compound is prepared by condensation of prednisolone 21-methanesulfonate (I) with sodium 3-sulfobenzoate (II) in DMF/H2O, followed by conversion to the corresponding sodium salt with aqueous sodium acetate.

The title compound is prepared by two alternative methods. Sulfonation of benzoic acid (I) with hot chlorosulfonic acid affords 3-carboxybenzenesulfonyl chloride (II). After conversion of (II) to the pyridine complex, coupling with prednisolone (III) produces the target 21-sulfobenzoate ester, which is finally isolated as the title sodium salt by treatment with aqueous NaOH.