RWJ-28810-药物合成数据库

【药物名称】RWJ-28810

化学结构式(Chemical Structure):

参考文献No.	572927
标题:	Synthesis and selective class III type antiarrhythmic activity of 4-aroyl (and aryl)-1-aralkylpiperazines
作者:	Kanojia, R.M.; et al.
来源:	219th ACS Natl Meet (March 26 2000, San Francisco) 2000,Abst MEDI 204

合成路线图解说明: The acylation of piperazine (II) with 4-nitrobenzoyl chloride (I) afforded a mixture of monoacylated (III) and diacylated (IV) products, which were separated by chromatography. Subsequent alkylation of monosubstituted piperazine (III) with 4-nitrophenethyl bromide (V) in the presence of K2CO3 and NaI yielded the title compound.

参考文献No.	604000
标题:	Synthesis and class III type antiarrhythmic activity of 4-aroyl (and aryl)-1-aralkylpiperazines
作者:	Kanojia, R.M.; Salata, J.J.; Kauffman, J.
来源:	Bioorg Med Chem Lett 2000,10(24),2819

合成路线图解说明: The acylation of piperazine (II) with 4-nitrobenzoyl chloride (I) afforded a mixture of monoacylated (III) and diacylated (IV) products, which were separated by chromatography. Subsequent alkylation of monosubstituted piperazine (III) with 4-nitrophenethyl bromide (V) in the presence of K2CO3 and NaI yielded the title compound.