-药物合成数据库

【药物名称】

化学结构式(Chemical Structure):

参考文献No.	573046
标题:	Cyclin-dependent kinase inhibition by new C-2 alkynylated purine derivatives and molecular structure of a CDK2 - Inhibitor complex
作者:	Legraverend, M.; Tunnah, P.; Noble, M.; Ducrot, P.; Ludwig, O.; Grierson, D.S.; Leost, M.; Meijer, L.; Endicott, J.
来源:	J Med Chem 2000,43(7),1282

合成路线图解说明: Condensation of 6-chloro-2-iodo-9-isopropylpurine (I) with 4-chlorobenzylamine (II) in hot EtOH afforded the 6-(benzylamino)purine (III). Subsequent Suzuki coupling of (III) with 3-methylpent-1-yn-3-ol (IV) in the presence of Pd(0) and CuI produced the target 2-ethynylpurine derivative.