【药物名称】alpha-TEA
化学结构式(Chemical Structure):
参考文献No.42750
标题:Tocopherols, tocotrienols, other chroman and side chain derivs. and uses thereof
作者:Liu, S.; Kline, K.; Sanders, B.G.; Hurley, L.; Gardner, R.; Menchaca, M.; Yu, W.; Ramanan, P.N.; Israel, K. (Research Development Foundation )
来源:EP 1115398; JP 2002526446; US 6417223; WO 0016772
合成路线图解说明:

Alkylation of R,R,R-alpha-tocopherol (I) with methyl bromoacetate in the presence of NaOH in DMF takes place with simultaneous hydrolysis of the methyl ester function to furnish the title carboxylic acid.

参考文献No.62230
标题:Tocopherols, tocotrienols, other chroman and side chain derivs. and uses thereof
作者:Liu, S.; Kline, K.; Sanders, R.G.; Hurley, L.; Gardner, R.; Menchaca, M.; Yu, W.; Ramanan, P.N.; Israel, K. (Research Development Foundation )
来源:WO 0158889
合成路线图解说明:

Alkylation of R,R,R-alpha-tocopherol (I) with methyl bromoacetate in the presence of NaOH in DMF takes place with simultaneous hydrolysis of the methyl ester function to furnish the title carboxylic acid.

参考文献No.62231
标题:Tocopherols, tocotrienols, other chroman and side chain derivs. and uses thereof
作者:Kline, K.; Sanders, B.G.; Yu, W. (Research Development Foundation )
来源:US 2002107207; US 6703384
合成路线图解说明:

Alkylation of R,R,R-alpha-tocopherol (I) with methyl bromoacetate in the presence of NaOH in DMF takes place with simultaneous hydrolysis of the methyl ester function to furnish the title carboxylic acid.

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