-药物合成数据库

【药物名称】

化学结构式(Chemical Structure):

参考文献No.	574786
标题:	Synthesis and in vitro evaluation of novel morpholinyl- and methylpiperazinylacyloxyalkyl prodrugs of 2-(6-methoxy-2-naphthyl)propionic acid (naproxen) for topical drug delivery
作者:	Rautio, J.; Nevalainen, T.; Taipale, H.; Vepsalainen, J.; Gynther, J.; Laine, K.; Jarvinen, T.
来源:	J Med Chem 2000,43(8),1489

合成路线图解说明: The hydroxyethyl ester of naproxen (II) was synthesized by treatment of the sodium salt of naproxen (I) with 2-bromoethanol. Condensation of (II) with (4-methyl-1-piperazinyl)acetic acid (III) in the presence of dicyclohexylcarbodiimide and 4-(dimethylamino)pyridine yielded the title compound.