HI-244-药物合成数据库

【药物名称】HI-244

化学结构式(Chemical Structure):

参考文献No.	48446
标题:	Phenethyl-thiourea cpds. and use
作者:	Ventalachalam, T.K.; Uckum, F.M. (Parker Hughes Institute)
来源:	US 6207688

合成路线图解说明: Reaction of 2-amino-5-bromopyridine (I) with thiocarbonyldiimidazole (II) afforded the thioimidazolide (III). This was then condensed with 4-methylphenetylamine (IV) in hot DMF to produce the required thiourea.

参考文献No.	582702
标题:	N-[2-(4-Methylphenyl)ethyl]-N'-[2-(5-bromopyridyl)]thiourea as a potent inhibitor of NNRTI-resistant and multidrug-resistant human immunodeficiency virus type 1
作者:	Uckun, F.M.; Mao, C.; Pendergrass, S.; Maher, D.; Zhu, D.; Tuel-Ahlgren, L.; Venkatachalam, T.K.
来源:	Antivir Chem Chemother 2000,11(2),135

合成路线图解说明: Reaction of 2-amino-5-bromopyridine (I) with thiocarbonyldiimidazole (II) afforded the thioimidazolide (III). This was then condensed with 4-methylphenetylamine (IV) in hot DMF to produce the required thiourea.