【药物名称】
化学结构式(Chemical Structure):
参考文献No.45416
标题:Acetylated and related analogues of chicoric acid as HIV integrase inhibitors
作者:Zhaiwei, L.; Zhao, H.; Neamati, N.; Burke, T.R.; Pommier, Y. (US Department of Health & Human Services)
来源:WO 0063152
合成路线图解说明:

Reaction of di-tert-butyl D-tartrate (I) with 3,4-diacetylcaffeoyl chloride (II) in the presence of pyridine gave the chicoric acid derivative (III). The tert-butyl ester groups were then cleaved by treatment with trifluoroacetic acid in CH2Cl2.

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