-药物合成数据库

【药物名称】

化学结构式(Chemical Structure):

参考文献No.	575413
标题:	Synthesis and biological activity of novel 2-trifluoromethylbenzimidazole derivatives
作者:	Hernandez, F.; Cedillo, R.; Navarrete, G.; Castillo, R.; Morales, R.; Y閜ez, L.; Tapia, A.
来源:	219th ACS Natl Meet (March 26 2000, San Francisco) 2000,Abst MEDI 146

合成路线图解说明: The required phenylenediamine (II) was prepared by catalytic hydrogenation of 4-chloro-N-methyl-2-nitroaniline (I) over Raney-Nickel. Cyclocondensation of phenylenediamine (II) with 50% aqueous CF3COOH gave the corresponding 2-(trifluoromethyl)benzimidazole derivative.

参考文献No.	606958
标题:	Synthesis and antiparasitic activity of 2-(trifluoromethyl)-benzimidazole derivatives
作者:	Navarrete-V醶quez, G.; Cedillo, R.; Hernandez-Campos, A.; Yepez, L.; Hernadez-Luis, F.; Valdez, J.; Morales, R.; Cortes, R.; Hernandez, M.; Castillo, R.
来源:	Bioorg Med Chem Lett 2001,11(2),187

合成路线图解说明: The required phenylenediamine (II) was prepared by catalytic hydrogenation of 4-chloro-N-methyl-2-nitroaniline (I) over Raney-Nickel. Cyclocondensation of phenylenediamine (II) with 50% aqueous CF3COOH gave the corresponding 2-(trifluoromethyl)benzimidazole derivative.