Benznidazole-药物合成数据库

【药物名称】Benznidazole

化学结构式(Chemical Structure):

参考文献No.	27056
标题:	Novel imidazole derivs. and a process for the manufacture thereof
作者:	Beaman, A.G.; Duschinsky, R.; Tautz, W.P. (F. Hoffmann-La Roche AG)
来源:	GB 1138529

合成路线图解说明: The condensation of 2-nitroimidazole (I) with methyl chloroacetate (II) by means of sodium methoxide in hot DMF gives methyl (2-nitro-1-imidazolyl)acetate (III), which is then treated with ethanolamine (IV) in methanol.

合成路线图解说明: The condensation of 2-nitroimidazole (I) with methyl chloroacetate (II) by means of sodium methoxide in methanol - DMF at 150 C gives methyl 2-nitro-1-imidazolylacetate (III), which is then condensed with benzylamine (IV) in methanol.

参考文献No.	612429
标题:	Benznidazole
作者:	Casta馿r, J.; Roberts, P.J.
来源:	Drugs Fut 1977,2(9),568

合成路线图解说明: The condensation of 2-nitroimidazole (I) with methyl chloroacetate (II) by means of sodium methoxide in methanol - DMF at 150 C gives methyl 2-nitro-1-imidazolylacetate (III), which is then condensed with benzylamine (IV) in methanol.