S-33113-1, S-33113-药物合成数据库

【药物名称】S-33113-1, S-33113

化学结构式(Chemical Structure):

参考文献No.	43196
标题:	Derivs. of dihydro- and tetrahydrochinoline as a medicinal antioxidants
作者:	Lestage, P.; Dorey, G.; Casara, P.; Lockhart, B. (ADIR et Cie.)
来源:	EP 0995743; FR 2784988; JP 2000128865

合成路线图解说明: Condensation of phenetidine (I) with 1-ethynyl-1-chlorocyclohexane (II) by means of CuCl and Et3N gave the propargyl aniline (III). This was then cyclized in the presence of copper catalyst in refluxing toluene to furnish the target dihydroquinoline.

参考文献No.	582838
标题:	New quinolinic derivatives as centrally active antioxidants
作者:	Dorey, G.; Lockhart, B.; Lestage, P.; Casara, P.
来源:	Bioorg Med Chem Lett 2000,10(9),935

合成路线图解说明: Condensation of phenetidine (I) with 1-ethynyl-1-chlorocyclohexane (II) by means of CuCl and Et3N gave the propargyl aniline (III). This was then cyclized in the presence of copper catalyst in refluxing toluene to furnish the target dihydroquinoline.