VUF-5574-药物合成数据库

【药物名称】VUF-5574

化学结构式(Chemical Structure):

参考文献No.	578656
标题:	Isoquinoline and quinazoline urea analogues as antagonists for the human adenosine A3 receptor
作者:	van Muijlwijk-Koezen, J.E.; Timmerman, H.; van der Goot, H.; Menge, W.M.P.B.; Frijtag von Drabbe K黱zel, J.; de Groote, M.; Ijzerman, A.P.
来源:	J Med Chem 2000,43(11),2227

合成路线图解说明: The amide anion obtained from 2-aminobenzonitrile (I) and NaH in THF was added to 3-cyanopyridine (II) yielding 2-(3-pyridyl)-4-aminoquinazoline (III). This was then condensed with 2-methoxyphenyl isocyanate (IV) to furnish the title urea.