【药物名称】MRS-1743
化学结构式(Chemical Structure):
参考文献No.578075
标题:Methanocarba analogues of purine nucleosides as potent and selective adenosine receptor agonists
作者:Jacobson, K.A.; Ji, X.; Li, A.-H.; Melman, N.; Siddiqui, M.A.; Shin, K.-J.; Marquez, V.E.; Ravi, G.
来源:J Med Chem 2000,43(11),2196
合成路线图解说明:

The known methanocarba-adenosine (I) was alkylated with 3-iodobenzyl bromide (II) in hot DMF to give the intermediate ammonium salt (III), which was then subjected to Dimroth rearrangement with ammonium hydroxide to produce the title compound.

Drug Information Express,Drug R&D,Chemical Database,Patent Search.
Copyright © 2006-2024 Drug Future. All rights reserved.Contact Us