【药物名称】
化学结构式(Chemical Structure):
参考文献No.581813
标题:Synthesis and binding affinities of 4-diarylaminotropanes, a new class of delta opioid agonists
作者:Boyd, R.E.; Carson, J.R.; Codd, E.E.; Gauthier, A.D.; Neilson, L.A.; Zhang, S.-P.
来源:Bioorg Med Chem Lett 2000,10(10),1109
合成路线图解说明:

The reductive alkylation of tropinone (I) with aniline (II) using either NaBH4 or NaBH(OAc)3 as the reducing agent furnished the endo-isomer (III). Arylation of amine (III) with t-butyl 4-bromobenzoate (IV) produced the (diarylamino)tropane (V). Acid cleavage of the tert-butyl ester of (V) gave acid (VI), which was further coupled to diethylamine, yielding amide (VII). Demethylation of tropane (VII) with 1-chloroethyl chloroformate, followed by methanolysis of the resulting carbamate (VIII), provided the secondary amine (IX). This was finally subjected to reductive alkylation with 3,4-methylenedioxybenzaldehyde (X) to give the title compound.

Drug Information Express,Drug R&D,Chemical Database,Patent Search.
Copyright © 2006-2024 Drug Future. All rights reserved.Contact Us