Y-39041-药物合成数据库

【药物名称】Y-39041

化学结构式(Chemical Structure):

参考文献No.	39054
标题:	Piperazine cpds. and medicinal use thereof
作者:	Adachi, K.; Moimoto, H.; Aoki, Y.; Hisadome, M.; Hanano, T. (Welfide Corporation)
来源:	EP 1029851; WO 9919301

合成路线图解说明: Curtius rearrangement of 1-phenyl-1-cyclopropanecarboxylic acid (I) afforded amine (II), which was subsequently acetylated to produce amide (III) (1). Chloromethylation of (III) by means of chloromethyl methyl ether and TiCl4 gave rise to benzyl chloride (IV). This was finally condensed with pyrimidylpiperazine (V) in the presence of K2CO3 to yield the title compound.

参考文献No.	582841
标题:	Novel DMARDs on the basis of a new concept of dual cytokine regulation, TNF-alpha suppression and IL-10 augmentation
作者:	Hanano, T.; Adachi, K.; Aoki, Y.; Morimoto, H.; Naka, Y.; Hisadome, M.; Fukuda, T.; Sumichika, H.
来源:	Bioorg Med Chem Lett 2000,10(9),881

合成路线图解说明: Curtius rearrangement of 1-phenyl-1-cyclopropanecarboxylic acid (I) afforded amine (II), which was subsequently acetylated to produce amide (III) (1). Chloromethylation of (III) by means of chloromethyl methyl ether and TiCl4 gave rise to benzyl chloride (IV). This was finally condensed with pyrimidylpiperazine (V) in the presence of K2CO3 to yield the title compound.