【药物名称】ALX-2226
化学结构式(Chemical Structure):
参考文献No.582839
标题:Pyrrolo[3,2,1-ij]quinoline derivatives, a 5-HT2c receptor agonist with selectivity over the 5-HT2a receptor: Potential therapeutic applications for epilepsy and obesity
作者:Isaac, M.; Slassi, A.; O'Brien, A.; Edwards, L.; MacLean, N.; Bueschkens, D.; Lee, D.K.; McCallum, K.L.; De Lannoy, I.; Demchyshyn, L.; Kamboj, R.
来源:Bioorg Med Chem Lett 2000,10(9),919
合成路线图解说明:

Nitrosation of 7-chloro-3,4-dihydro-2H-1,4-benzothiazine (I) by means of NaNO2 and H2SO4, followed by reduction with LiAlH4, affords amino derivative (II). Finally, Fischer indole cyclization of (II) with 4-chlorobutanal (III) in refluxing aqueous methanol yields the desired product.

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