【药物名称】FI-6828K
化学结构式(Chemical Structure):
参考文献No.43659
标题:2-Alkyl-5-halo-3-[2'-(tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazole-4-carboxaldehyde acetal derivs., their preparation and use
作者:Anglada, L.; Foguet, R.; Ortiz, J.A.; Sacrist醤, A.; Castell? J.M. (Ferrer Internacional SA)
来源:WO 0031071
合成路线图解说明:

The known 2-butyl-5-chloro-3-[2'-(tetrazol-5-yl)biphenyl-4-ylmethyl]-3H-imidazole-4-carboxaldehyde (I) was converted into the corresponding ethylene acetal (II) by treatment with ethylene glycol and trimethylchlorosilane in CH2Cl2. The title potassium salt was then obtained by treatment of an aqueous suspension of (II) with KOH, followed by freeze-drying.

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