AWD-12-343-药物合成数据库

【药物名称】AWD-12-343

化学结构式(Chemical Structure):

参考文献No.	583863
标题:	AWD 12-343, a new orally active PDE 4 inhibitor - Synthesis and comparison with SB 207499, rolipram and AWD 12-281
作者:	H鰂gen, N.; et al.
来源:	27th Natl Med Chem Symp (June 13 2000, Kansas City) 2000,Abst B-19

合成路线图解说明: Alkylation of 5-fluoroindole (I) with 4-fluorobenzyl chloride (II) provided the N-benzyl indole (III). Subsequent reaction of (III) with oxalyl chloride furnished the indolylglyoxylic acid chloride (IV). This was finally coupled with 4-amino-3,5-dichloropyridine (V) to afford the corresponding amide.

参考文献No.	593852
标题:	AWD 12-343, a new orally active PDE 4 inhibitor - Synthesis and comparison with SB 207499, rolipram and AWD 12-281
作者:	Egerland, U.; Kronbach, T.; H鰂gen, N.; Poppe, H.; K黶ters, S.; szelenyi, S.
来源:	16th Int Symp Med Chem (Sept 18 2000, Bologna) 2000,Abst PA-79

合成路线图解说明: Alkylation of 5-fluoroindole (I) with 4-fluorobenzyl chloride (II) provided the N-benzyl indole (III). Subsequent reaction of (III) with oxalyl chloride furnished the indolylglyoxylic acid chloride (IV). This was finally coupled with 4-amino-3,5-dichloropyridine (V) to afford the corresponding amide.