【药物名称】
化学结构式(Chemical Structure):
参考文献No.584832
标题:Regio- and stereoselective cycloadditions of cyclic nitrones to maleic diamide forced in a peptide: Synthesis of potent ligands of human NK-2 receptor
作者:Valenza, S.; Cordero, F.M.; Brandi, A.; Guidi, A.; Altamura, M.; Giolitti, A.; Giuntini, F.; Pasqui, F.; Renzetti, A.R.; Maggi, C.A.
来源:J Org Chem 2000,65(13),4003
合成路线图解说明:

The cycloaddition reaction of nitrone (II) to the maleic acid diamide cyclic derivative (I) in hot DMSO produced a 3:7 mixture of adducts (III) and (IV). The same reaction in toluene as the solvent afforded a 4:30 mixture of (III) and (IV). The desired minor isomer (III) was then isolated by flash chromatography.

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