【药物名称】
化学结构式(Chemical Structure):
参考文献No.588387
标题:Cell adhesion antagonists: Synthesis and evaluation of a novel series of phenylalanine based inhibitors
作者:Harriman, G.C.B.; Schwender, C.F.; Gallant, D.; Cochran, N.A.; Briskin, M.J.
来源:Bioorg Med Chem Lett 2000,10(14),1497
合成路线图解说明:

Coupling of N-Boc-phenylalanine (I) with amine (II) by means of HBTU and DIEA provides amide (III), whose Boc group is removed by treatment with HCl in dioxane to afford amine hydrochloride (IV). Finally, the target compound is obtained by reductive amination between amine (IV) and aldehyde (V) in MeOH in the presence of NaCNBH3.

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