-药物合成数据库

【药物名称】

化学结构式(Chemical Structure):

参考文献No.	588452
标题:	Synthesis and structure-activity relationship studies of conformationally restricted analogs of 2-chloro-4-trifluoromethylpyrimidine-5-[N-(3',5'-bis(trifluoromethyl)-phenyl)]carboxamide
作者:	Suto, M.J.; Suto, C.; Goldman, M.E.; Palanki, M.S.S.; Erdman, P.E.
来源:	Med Chem Res 2000,10(1),19

合成路线图解说明: Reduction of nitrothiophenol (I) by hydrogenation over Pd/C in THF affords substituted aniline (II), which is then cyclized with 2,4-dichloropyrimidine-5-carbonyl chloride (III) in THF in the presence of Amberlyst A-27 to yield the final product.