-药物合成数据库

【药物名称】

化学结构式(Chemical Structure):

参考文献No.	44975
标题:	Basic alpha-aminoalkylphosphonate derivs.
作者:	Powers, J.C.; Ni, L.; Jackson, D.S. (Georgia Technology Research Corp.)
来源:	US 5952307

合成路线图解说明: Coupling of PhCH2OOC-Pro-OH (I) with diphenyl (1-amino-2-phenylethyl)phosphonate (II) by means of DCC in THF affords derivative (III), which is then subjected to hydrogenation followed by coupling with PhCH2OOC -Val-OH (IV) by means of DCC to provide peptide derivative (V). Finally, reaction of (V) with succinic anhydride in EtOAc under an atmosphere of H2 in the presence of Pd/C provides the target compound.

参考文献No.	594948
标题:	Irreversible inhibition of serine proteases by peptide derivatives of (alpha-aminoalkyl)phosphonate diphenyl esters
作者:	Oleksyszym, J.; Powers, J.C.
来源:	Biochemistry 1991,30(2),485

合成路线图解说明: Coupling of PhCH2OOC-Pro-OH (I) with diphenyl (1-amino-2-phenylethyl)phosphonate (II) by means of DCC in THF affords derivative (III), which is then subjected to hydrogenation followed by coupling with PhCH2OOC -Val-OH (IV) by means of DCC to provide peptide derivative (V). Finally, reaction of (V) with succinic anhydride in EtOAc under an atmosphere of H2 in the presence of Pd/C provides the target compound.