【药物名称】JNJ-2408068, R-170591
化学结构式(Chemical Structure):
参考文献No.46651
标题:Respiratory syncytial virus replication inhibitors
作者:Sommen, F.M.; Andries, K.J.L.M.; Guillemont, J.E.G.; Lacrampe, J.F.A.; Janssens, F.E.; Meersman, K.P.M.-J. (Janssen Pharmaceutica NV)
来源:WO 0100611
合成路线图解说明:

Condensation of ethyl carboxylate (I) with chloromethyl derivative (II) by heating with TEA in DMF affords compound (III), which is hydrolyzed with aqueous HBr to provide piperidine (IV). Compound (IV) is then coupled to bromo derivative (V) by means of Na2CO3 in 2-butanone to give protected (VI), whose Boc group is finally removed by treatment with HCl in refluxing 2-propanol to furnish the desired product.

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