【药物名称】TAK-457
化学结构式(Chemical Structure):
参考文献No.37486
标题:Azole cpds., their production and their use
作者:Itoh, K.; Okonogi, K.; Kitazaki, T. (Takeda Chemical Industries, Ltd.)
来源:EP 0973768; JP 1999228548; JP 2000198773; WO 9843970
合成路线图解说明:

The alkylation of the triazole derivative (I) (compound 293408) with bromomethyl acetate (II) in hot acetonitrile produced the triazolium bromide salt (III). This was then treated either with ion-exchange resin or with a saturated solution of NaCl to produce the desired chloride salt. The analogous alkylation of (I) with iodomethyl acetate (IV) produced the iodide salt (V), which was finally converted to the corresponding chloride by treatment with a saturated solution of NaCl.

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