Mitsunobu coupling of 3,3-tetramethyleneglutarimide (I) with 1-chloro-2-propanol (II) afforded the N-(2-chloro-1-methylethyl) glutarimide (III). This was then condensed with N-(2,5-dichlorophenyl)piperazine (IV) in the presence of Et3N at 180 C to furnish the title compound.