Sunifiram, DM-235-药物合成数据库

【药物名称】Sunifiram, DM-235

化学结构式(Chemical Structure):

参考文献No.	591935
标题:	1,4-Diazabicyclo[4.3.0]nonan-9-ones and 1,4-diamidopiperazines as new classes of highly potent nootropic drugs
作者:	Bellucci, C.; Ghelardini, C.; Dei, S.; Bartolini, A.; Galeotti, N.; Romanelli, M.N.; Gualtiere, F.; Manetti, D.; Scapecchi, S.; Teodori, E.
来源:	16th Int Symp Med Chem (Sept 18 2000, Bologna) 2000,Abst PB-119

合成路线图解说明: Acylation of N-benzylpiperazine (I) with propionyl chloride afforded amide (II). Hydrogenolysis of the N-benzyl protecting group of (II) over Pd/C then gave N-propionyl piperazine (III), which was finally condensed with benzoyl chloride to yield the title diamide.

参考文献No.	596239
标题:	Molecular simplification of 1,4-diazabicyclo[4.3.0]nonan-9-ones gives piperazine derivatives that maintain high nootropic activity
作者:	Mannetti, D.; Ghelardini, C.; Bartolini, A.; Dei, S.; Galeotti, N.; Gualtiere, F.; Romanelli, M.N.; Teodori, E.
来源:	J Med Chem 2000,43(23),4499

合成路线图解说明: Acylation of N-benzylpiperazine (I) with propionyl chloride afforded amide (II). Hydrogenolysis of the N-benzyl protecting group of (II) over Pd/C then gave N-propionyl piperazine (III), which was finally condensed with benzoyl chloride to yield the title diamide.