【药物名称】MEB
化学结构式(Chemical Structure):
参考文献No.46172
标题:Derivs. of butyric acid and uses thereof
作者:Gilbert, K.; Fifer, E.K. (University of Arkansas)
来源:US 6407107; WO 0073257
合成路线图解说明:

The title butyrate ester is prepared by acylation of N-(2-hydroxyethyl)morpholine (I) with butyryl chloride (II), followed by isolation as the corresponding hydrochloride salt.

参考文献No.591599
标题:Potential clinical use of butyric acid derivatives to induce antigen-specific T cell inactivation
作者:Gilbert, K.M.; Wahid, R.; Fecher, N.P.; Freeman, J.P.; Fifer, E.K.
来源:J Pharmacol Exp Ther 2000,294(3),1146
合成路线图解说明:

The title butyrate ester is prepared by acylation of N-(2-hydroxyethyl)morpholine (I) with butyryl chloride (II), followed by isolation as the corresponding hydrochloride salt.

参考文献No.735280
标题:Synthesis of hydrochlorides of N-ethanolmorpholine esters and aliphatic acids
作者:Chrzaszczewska, A.; Starksi, H.
来源:Soc Sci Lodz Acta Chim 1967,12133
合成路线图解说明:

The title butyrate ester is prepared by acylation of N-(2-hydroxyethyl)morpholine (I) with butyryl chloride (II), followed by isolation as the corresponding hydrochloride salt.

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