Lidofenin, 99Tcm-HIDA, Hepato-Scan-药物合成数据库

【药物名称】Lidofenin, 99Tcm-HIDA, Hepato-Scan

化学结构式(Chemical Structure):

参考文献No.	607177
标题:	Tissue distribution of technetium-99m and carbon-14 labeled N-(2,6-dimethylphenylcarbamoylmethyl)iminodiacetic acid
作者:	Callery, P.S.; Faith, W.C.; Loberg, M.D.; Fields, A.T.; Harvey, E.B.; Cooper, M.D.
来源:	J Med Chem 1976,19(7),962-964

合成路线图解说明: Compound can be prepared in two related ways: 1) The acylation of 2,6-dimethylaniline (I) with chloroacetyl chloride (II) in acetic acid gives omega-chloro-2,6-dimethylacetanilide (III), which is then condensed with disodium salt of iminodiacetic acid (IV) in refluxing ethanol-water. 2) The reaction of (III) with ammonia in ethanol gives omega-amino-2,6-dimethylacetanilide (V), which is finally treated with chloroacetic acid (A) and NaOH in refluxing 95% ethanol.

参考文献No.	800515
标题:	Lidofenin
作者:	Casta馿r, J.; Blancafort, P.; Serradell, M.N.; Paton, D.M.
来源:	Drugs Fut 1979,4(5),342

合成路线图解说明: Compound can be prepared in two related ways: 1) The acylation of 2,6-dimethylaniline (I) with chloroacetyl chloride (II) in acetic acid gives omega-chloro-2,6-dimethylacetanilide (III), which is then condensed with disodium salt of iminodiacetic acid (IV) in refluxing ethanol-water. 2) The reaction of (III) with ammonia in ethanol gives omega-amino-2,6-dimethylacetanilide (V), which is finally treated with chloroacetic acid (A) and NaOH in refluxing 95% ethanol.